Copper(II) <i>N</i>,<i>N</i>,<i>O</i>-Chelating Complexes as Potential Anticancer Agents

Three novel dinuclear Cu(II) complexes based on a N,N,O-chelating salphen-like ligand scaffold and bearing varying aromatic substituents (?H, ?Cl, ?Br) have been synthesized characterized. The experimental computational data obtained suggest that all three exist in the dimeric form solid state adopt same conformation. mass spectrometry electron paramagnetic resonance results indicate structure coexists with monomeric solution upon solvent (dimethyl sulfoxide water) coordination. exhibit high potentiality as ROS generators, Cu(II)/Cu(I) redox potential inside biological window, thus being able to biologically undergo cycling. formation of is one most promising reported cell death mechanisms for metal offer an inherent selectivity cancer cells. In vitro cytotoxic studies two different lines (HeLa MCF7) normal fibroblast line show selective cytotoxicity cells (IC50 about 25 ?M HeLa cells, which range cisplatin improved respect carboplatin), hence placing this metallic core be explored design future tailor-made compounds.